Nucleolar histone deacetylases HDT1, HDT2 and HDT3 regulate plant reproductive development

Nucleolar histone deacetylases HDT1, HDT2 and HDT3 regulate plant reproductive development

Host: Pan Kairui

Date: 17 Nov 2021

Abstract:

Nucleolus is a membrane-less organelle where ribosomes are assembled and rRNAs transcribed and processed. The assembled ribosomes composed of ribosomal proteins and rRNAs synthesize proteins for cell survival. In plants, the loss of nucleolar ribosomal proteins often causes gametophytically or embryonically lethality. The amount of rRNAs are under stringent regulation according to demand and partially switched off by epigenetic modifications. However, the molecular mechanism for the selective activation or silencing is still unclear, and the transcriptional coordination of rRNAs and ribosomal proteins is also unknown. Here we report the critical role of three Arabidopsis nucleolar protein HDT1, HDT2 and HDT3 in fertility and transcription of rDNAs and rRNA processing-related genes through histone acetylation. This study highlights the important roles of transcriptional repression of ribosome biogenesis-related genes for plant reproductive development.

Source: Journal of Genetics and Genomics (2021)